Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles.

Détails

ID Serval
serval:BIB_745AC7CD5CE7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles.
Périodique
Molecular Ecology
Auteur(s)
Orozco-terWengel P., Kapun M., Nolte V., Kofler R., Flatt T., Schlötterer C.
ISSN
1365-294X (Electronic)
ISSN-L
0962-1083
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
21
Numéro
20
Pages
4931-4941
Langue
anglais
Résumé
The genomic basis of adaptation to novel environments is a fundamental problem in evolutionary biology that has gained additional importance in the light of the recent global change discussion. Here, we combined laboratory natural selection (experimental evolution) in Drosophila melanogaster with genome-wide next generation sequencing of DNA pools (Pool-Seq) to identify alleles that are favourable in a novel laboratory environment and traced their trajectories during the adaptive process. Already after 15 generations, we identified a pronounced genomic response to selection, with almost 5000 single nucleotide polymorphisms (SNP; genome-wide false discovery rates < 0.005%) deviating from neutral expectation. Importantly, the evolutionary trajectories of the selected alleles were heterogeneous, with the alleles falling into two distinct classes: (i) alleles that continuously rise in frequency; and (ii) alleles that at first increase rapidly but whose frequencies then reach a plateau. Our data thus suggest that the genomic response to selection can involve a large number of selected SNPs that show unexpectedly complex evolutionary trajectories, possibly due to nonadditive effects.
Mots-clé
Adaptation, Physiological/genetics, Alleles, Animals, Biological Evolution, Computational Biology, Drosophila melanogaster/genetics, Drosophila melanogaster/physiology, Environment, Female, Gene Frequency, Laboratories, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Selection, Genetic, Sequence Analysis, DNA
Pubmed
Web of science
Création de la notice
28/01/2013 12:31
Dernière modification de la notice
03/03/2018 18:21
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