The Swiss Multiple Sclerosis Cohort-Study (SMSC): A Prospective Swiss Wide Investigation of Key Phases in Disease Evolution and New Treatment Options.

Détails

Ressource 1Télécharger: BIB_745A35B87D48.P001.pdf (1300.87 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_745A35B87D48
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Swiss Multiple Sclerosis Cohort-Study (SMSC): A Prospective Swiss Wide Investigation of Key Phases in Disease Evolution and New Treatment Options.
Périodique
Plos One
Auteur(s)
Disanto G., Benkert P., Lorscheider J., Mueller S., Vehoff J., Zecca C., Ramseier S., Achtnichts L., Findling O., Nedeltchev K., Radue E.W., Sprenger T., Stippich C., Derfuss T., Louvion J.F., Kamm C.P., Mattle H.P., Lotter C., Du Pasquier R., Schluep M., Pot C., Lalive P.H., Yaldizli Ö., Gobbi C., Kappos L., Kuhle J., SMSC Scientific Board
Contributeur(s)
SMSC Scientific Board, Ramseier S., Achtnichts L., Findling O., Saxer J., Nedeltchev K., Remonda L., Boxheimer L., Kuhle J., Kappos L., Yaldizli£££Özguer£££ Ö. , Derfuss T., Sprenger T., Limberg M., Scheerer I., Orleth A., Treppke F., Beregi E., Stippich C., Reinhardt J., Fellner I., Würfel J., Radue EW., Thoeni A., Palatini A., Pauli-Magnus C., Fabbro T., Benkert P., Roesler A., Mechati S., Louvion JF., Kamm C., Chan A., Mattle H., Salmen A., Kaeser M., Wagner F., Verma R., Lalive P., Di Marco M., Haller S., Lovblad KO., Du Pasquier R., Schluep M., Pot C., Granziera C., Hagmann P., Maeder P., Gobbi C., Zecca C., Disanto G., Tschuor S., Cianfoni A., Müller S., Vehoff J., Weber J., Lotter C.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
11
Numéro
3
Pages
e0152347
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
The mechanisms leading to disability and the long-term efficacy and safety of disease modifying drugs (DMDs) in multiple sclerosis (MS) are unclear. We aimed at building a prospective cohort of MS patients with standardized collection of demographic, clinical, MRI data and body fluids that can be used to develop prognostic indicators and biomarkers of disease evolution and therapeutic response. The Swiss MS Cohort (SMSC) is a prospective observational study performed across seven Swiss MS centers including patients with MS, clinically isolated syndrome (CIS), radiologically isolated syndrome or neuromyelitis optica. Neurological and radiological assessments and biological samples are collected every 6-12 months. We recruited 872 patients (clinically isolated syndrome [CIS] 5.5%, relapsing-remitting MS [RRMS] 85.8%, primary progressive MS [PPMS] 3.5%, secondary progressive MS [SPMS] 5.2%) between June 2012 and July 2015. We performed 2,286 visits (median follow-up 398 days) and collected 2,274 serum, plasma and blood samples, 152 cerebrospinal fluid samples and 1,276 brain MRI scans. 158 relapses occurred and expanded disability status scale (EDSS) scores increased in PPMS, SPMS and RRMS patients experiencing relapses. Most RRMS patients were treated with fingolimod (33.4%), natalizumab (24.5%) or injectable DMDs (13.6%). The SMSC will provide relevant information regarding DMDs efficacy and safety and will serve as a comprehensive infrastructure available for nested research projects.
Mots-clé
Adult, Biomarkers/blood, Biomarkers/cerebrospinal fluid, Brain/radiography, Cohort Studies, Demography, Female, Fingolimod Hydrochloride/therapeutic use, Follow-Up Studies, Humans, Immunosuppressive Agents/therapeutic use, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis/diagnosis, Multiple Sclerosis/drug therapy, Natalizumab/therapeutic use, Prognosis, Prospective Studies, Recurrence, Switzerland
Pubmed
Web of science
Création de la notice
14/04/2016 17:45
Dernière modification de la notice
27/08/2018 11:09
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