Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma.

Détails

ID Serval
serval:BIB_744C57A5CB23
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma.
Périodique
Cell Biology and Toxicology
Auteur(s)
Vlachostergios P.J., Voutsadakis I.A., Papandreou C.N.
ISSN
1573-6822 (Electronic)
ISSN-L
0742-2091
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
29
Numéro
4
Pages
199-211
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish Document Type: Review
Résumé
The 26S proteasome constitutes an essential degradation apparatus involved in the consistent recycling of misfolded and damaged proteins inside cells. The aberrant activation of the proteasome has been widely observed in various types of cancers and implicated in the development and progression of carcinogenesis. In the era of targeted therapies, the clinical use of proteasome inhibitors necessitates a better understanding of the molecular mechanisms of cell death responsible for their cytotoxic action, which are reviewed here in the context of sensitization of malignant gliomas, a tumor type particularly refractory to conventional treatments.
Pubmed
Web of science
Création de la notice
20/09/2013 18:28
Dernière modification de la notice
03/03/2018 18:21
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