Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans

Détails

ID Serval
serval:BIB_73E36CEAD13C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans
Périodique
Blood
Auteur(s)
Sakamoto N., Tsuji K., Muul L. M., Lawler A. M., Petricoin E. F., Candotti F., Metcalf J. A., Tavel J. A., Lane H. C., Urba W. J., Fox B. A., Varki A., Lunney J. K., Rosenberg A. S.
ISSN
0006-4971 (Print)
ISSN-L
0006-4971
Statut éditorial
Publié
Date de publication
2007
Volume
110
Numéro
2
Pages
501-8
Langue
anglais
Notes
Sakamoto, Norihisa
Tsuji, Kazuhide
Muul, Linda M
Lawler, Ann M
Petricoin, Emanuel F
Candotti, Fabio
Metcalf, Julia A
Tavel, Jorge A
Lane, H Clifford
Urba, Walter J
Fox, Bernard A
Varki, Ajit
Lunney, Joan K
Rosenberg, Amy S
eng
Intramural NIH HHS/
Research Support, N.I.H., Intramural
Blood. 2007 Jul 15;110(2):501-8. Epub 2007 Mar 29.
Résumé
Recent studies have demonstrated that cell populations intended for therapeutic purposes that are cultured in heterologous animal products can acquire xenoantigens, potentially limiting their utility. In investigations of the immune response to murine embryonic stem cells, we found that a strong antibody response was generated after the second infusion. Both polyclonal and monoclonal antibody responses, derived from immunized mice, were found to be specific for bovine apolipoprotein B-100, which binds to abundant low-density lipoprotein receptors on the cell surface and is internalized. Here we show that in the majority of patients administered 3 different types of cell-based therapies using cells grown in fetal calf serum-containing media, an antibody response to bovine apolipoprotein B-100 develops after the second infusion and is the dominant specificity. The known and potential clinical effects of such antibodies are discussed.
Mots-clé
Animals, Antibody Formation, Antigens, Heterophile/immunology, Apolipoprotein B-100/*immunology, Blood Banks, Cattle, Embryonic Stem Cells/immunology, Female, Fetal Blood/*immunology, Humans, Mice, Mice, Inbred C57BL, Mice, Inbred Strains/immunology, Mice, Transgenic, National Institutes of Health (U.S.), United States, *Vaccines
Pubmed
Création de la notice
01/11/2017 11:29
Dernière modification de la notice
03/03/2018 18:20
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