Relevance of animal models to the prophylaxis of infective endocarditis.

Détails

ID Serval
serval:BIB_73E1386089B8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Relevance of animal models to the prophylaxis of infective endocarditis.
Périodique
Journal of Antimicrobial Chemotherapy
Auteur(s)
Glauser M.P., Francioli P.
ISSN
0305-7453 (Print)
ISSN-L
0305-7453
Statut éditorial
Publié
Date de publication
09/1987
Peer-reviewed
Oui
Volume
20 Suppl A
Pages
87-98
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Intravascular or cardiac endothelial lesions may become colonized during bacteraemic episodes and lead to the development of bacterial endocarditis (BE). It has therefore long been recommended that patients with known cardiac lesions receive prophylactic antibiotics before undergoing procedures that might release bacteria into the blood stream. Because clinical trials of antibiotic prophylaxis of endocarditis cannot be conducted in humans for ethical as well as for statistical reasons (Durack, 1985), the questions of which antibiotic, what dosage, and for how long are a matter of controversy. Unfortunately, these questions can only be studied in animals, with all the limitations that this type of approach brings with it. However, animal experimental studies have helped in understanding the conditions and, to some extent, the mode of action of antibiotics in preventing the development of endocardial infection, thus allowing some rationale for devising prophylactic recommendations for the various patients at risk of developing BE.
Mots-clé
Animals, Anti-Bacterial Agents/therapeutic use, Cardiac Catheterization, Disease Models, Animal, Endocarditis, Bacterial/prevention & control, Humans, Rabbits, Rats
Pubmed
Web of science
Création de la notice
25/01/2008 18:07
Dernière modification de la notice
03/03/2018 18:20
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