Cytoarchitecture of serotonin-synthesizing neurons in the pontine tegmentum of the human brain

Détails

ID Serval
serval:BIB_73978BAD4D52
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cytoarchitecture of serotonin-synthesizing neurons in the pontine tegmentum of the human brain
Périodique
Synapse
Auteur(s)
Baker  K. G., Halliday  G. M., Halasz  P., Hornung  J. P., Geffen  L. B., Cotton  R. G., Tork  I.
ISSN
0887-4476 (Print)
Statut éditorial
Publié
Date de publication
04/1991
Volume
7
Numéro
4
Pages
301-20
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
We have employed immunohistochemical and morphometric procedures to study serotonin-synthesizing (PH8-immunoreactive) neurons in the pontine reticular formation of the adult human. PH8-immunoreactive neurons were found in three cytoarchitectural regions: the median raphe nucleus (MnR), oral pontine reticular nucleus (PnO), and supralemniscal region (group B9). On the basis of cell size, morphology, and position, it was possible to distinguish distinct subgroups within the MnR (dorsal, midline, and paramedian cell clusters) and within the PnO (dorsal and central cell clusters), whereas within the B9 there were no distinct cell clusters. We have estimated that there are approximately 125,000 PH8-immunoreactive neurons in the human pontine tegmentum; 64,400 in the MnR, 30,700 in PnO and 29,000 in B9. The large numbers of serotonin-synthesizing neurons in the human pontine tegmentum contrasts with their relative paucity in nonprimate species such as rats and cats. Nonhuman primates also have large numbers of pontine serotonergic neurons but the morphology of these neurons and their spatial arrangement is significantly different in humans. These results are discussed with respect to the possible projections and functions of these neurons in humans.
Mots-clé
Aged Computer Graphics Dendrites/ultrastructure Female Humans Immunoenzyme Techniques Male Models, Neurological Neurons/*cytology/metabolism Phenylalanine Hydroxylase/*analysis Pons/*anatomy & histology/metabolism Serotonin/*metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:22
Dernière modification de la notice
03/03/2018 18:19
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