The FMRP regulon: from targets to disease convergence.

Détails

ID Serval
serval:BIB_7385D5EF8FA4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The FMRP regulon: from targets to disease convergence.
Périodique
Frontiers in neuroscience
Auteur(s)
Fernández E., Rajan N., Bagni C.
ISSN
1662-4548 (Print)
ISSN-L
1662-453X
Statut éditorial
Publié
Date de publication
24/10/2013
Volume
7
Pages
191
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in 1991, many studies have primarily focused on understanding the function/s of this protein. Hundreds of potential FMRP mRNA targets and several interacting proteins have been identified. Here, we report the identification of FMRP mRNA targets in the mammalian brain that support the key role of this protein during brain development and in regulating synaptic plasticity. We compared the genes from databases and genome-wide association studies with the brain FMRP transcriptome, and identified several FMRP mRNA targets associated with autism spectrum disorders, mood disorders and schizophrenia, showing a potential common pathway/s for these apparently different disorders.

Mots-clé
Fmrp, RNA-binding proteins, autism, fragile X syndrome, local protein synthesis, major depressive disorders, schizophrenia, synaptic plasticity
Pubmed
Open Access
Oui
Création de la notice
06/03/2017 18:23
Dernière modification de la notice
08/05/2019 20:25
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