Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.

Détails

Ressource 1Télécharger: 28738793.pdf (490.69 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_734834187D90
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.
Périodique
BMC medical genetics
Auteur(s)
Sikhayeva N., Iskakova A., Saigi-Morgui N., Zholdybaeva E., Eap C.B., Ramanculov E.
ISSN
1471-2350 (Electronic)
ISSN-L
1471-2350
Statut éditorial
Publié
Date de publication
24/07/2017
Peer-reviewed
Oui
Volume
18
Numéro
1
Pages
76
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
We evaluated the associations between single nucleotide polymorphisms and different clinical parameters related to type 2 diabetes mellitus (T2DM), obesity risk, and metabolic syndrome (MS) in a Kazakh cohort.
A total of 1336 subjects, including 408 T2DM patients and 928 control subjects, were recruited from an outpatient clinic and genotyped for 32 polymorphisms previously associated with T2DM and obesity-related phenotypes in other ethnic groups. For association studies, the chi-squared test or Fisher's exact test for binomial variables were used. Logistic regression was conducted to explore associations between the studied SNPs and the risk of developing T2DM, obesity, and MS, after adjustments for age and sex.
After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2). In addition, examination of general unmatched T2DM and control cohorts revealed significant associations between T2DM and SNPsrs1799883 (FABP2) and rs9939609 (FTO). Furthermore, polymorphisms in the FTO gene were associated with increased obesity risk, whereas polymorphisms in the FTO and FABP2 genes were also associated with the risk of developing MS in general unmatched cohorts.
We confirmed associations between polymorphisms within the SLC30A8, TSPAN8/LGR5, FABP2, and FTO genes and susceptibility to T2DM in a Kazakh cohort, and revealed significant associations with anthropometric and metabolic traits. In particular, FTO and FABP2 gene polymorphisms were significantly associated with susceptibility to MS and obesity in this cohort.

Mots-clé
Adolescent, Adult, Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics, Asian Continental Ancestry Group, Diabetes Mellitus, Type 2/genetics, Diabetes Mellitus, Type 2/pathology, Ethnic Groups, Fatty Acid-Binding Proteins/genetics, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Kazakhstan, Male, Metabolic Syndrome X/genetics, Metabolic Syndrome X/pathology, Middle Aged, Obesity/genetics, Obesity/pathology, Polymorphism, Single Nucleotide, Risk Factors, Genetic variants, Kazakh cohort, Metabolic syndrome, Obesity, Type 2 diabetes mellitus
Pubmed
Web of science
Création de la notice
08/08/2017 10:43
Dernière modification de la notice
03/03/2018 18:19
Données d'usage