IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis.

Détails

ID Serval
serval:BIB_733963D36AA6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis.
Périodique
Microbes and Infection
Auteur(s)
Bourreau E., Ronet C., Couppié P., Sainte-Marie D., Tacchini-Cottier F., Launois P.
ISSN
1286-4579 (Print)
ISSN-L
1286-4579
Statut éditorial
Publié
Date de publication
2007
Volume
9
Numéro
8
Pages
1034-1041
Langue
anglais
Résumé
Cytokines are increasingly recognized as important components of the cellular immune responses to intracellular pathogens. In this study, we analyzed the production of TGF-beta, IL-10 and IFN-gamma by PBMC of unexposed naïve subjects and LCL patients after stimulation with live Leishmania guyanensis (L.g.). We demonstrated that IFN-gamma is produced in controls and LCL patients, IL-10 only in LCL patients and TGF-beta only in naïve subjects. Furthermore, in naive subjects, neutralization of TGF-beta induced IL-10 production. IL-10 produced in naïve subjects when TGF-beta is neutralized or in LCL patients did not modify the IFN-gamma production but inhibit reactive nitrogen species production. Analysis of the phenotype of IL-10 producing cells in naive subjects when TGF-beta is neutralized clearly showed that they are memory CD45RA- CD8+ T cells. In LCL patients, IL-10 producing cells are both CD45RA- CD4 and CD8+ T cells. The role of these IL-10 producing CD8+ T cells in the development of the diseases should be carefully evaluated.
Mots-clé
Animals, Antigens, CD45/metabolism, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Cell Line, Cells, Cultured, Humans, Immunologic Memory, Interleukin-10/biosynthesis, Leishmania guyanensis/pathogenicity, Leishmaniasis, Mucocutaneous/diagnosis, Leishmaniasis, Mucocutaneous/immunology, Lymphocyte Activation
Pubmed
Web of science
Création de la notice
24/01/2008 15:08
Dernière modification de la notice
20/08/2019 14:31
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