Biometal muscles to restore contractile function of weak heart

Détails

ID Serval
serval:BIB_7324F074CFFA
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Biometal muscles to restore contractile function of weak heart
Titre de la conférence
38th Congress of the European Society for Artificial Organs (ESAO 2011) and 4th Biennial Congress of the International Federation on Artificial Organs (IFAO 2011)
Auteur(s)
Michalis A., Tozzi P., Hayoz D., von Segesser L.K.
Adresse
Porto, Portugal, October 9-12, 2011
ISBN
0391-3988
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
34
Série
International Journal of Artificial Organs
Pages
614
Langue
anglais
Notes
Publication type : Meeting Abstract
Résumé
Objectives: Existing VADs are single-ventricle pumps needing anticoagulation. We developed a bi-ventricular external assist device that partially reproduces the physiological muscle function of the heart. This artificial muscle could wrap the heart and improve its contractile force.Methods: The device has a carbon fiber skeleton fitting a 30-40kg patient's heart, to which a Nitinol based artificial muscle is connected. The artificial muscle wraps both ventricles. The Nitinol fibers are woven on a Kevlar mesh surrounding each ventricle. The fibers are electrically driven with a dedicated control unit developed for this purpose. We assessed hemodynamic performances of this device using a previously described dedicated bench test. Volume ejected and pressure gradient have been measured with afterload ranging from 10 to 50mmHg.Results: With an afterload of 50mmHg the system has an ejection fraction of 4% on the right side and 5% on the left side. The system is able to generate a systolic ejection of 2.2mL on the right side and 3.25mL on the left side. With an afterload of 25mmHg the results are reduced of about 20%. The activation frequency can reach 80/minute resulting in a total volume displacement of 176mL/minute on the right side and 260mL/minute on the left side.Conclusions: These preliminary studies confirmed the possibility of improving the ejection fraction of a failing heart using artificial muscle for external cardiac compression avoiding anticoagulation therapy. This device could be helpful in weaning cardio-pulmonary bypass and/or for short-term cardio-circulatory support in pediatric population with cardiac failure.
Mots-clé
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Création de la notice
17/02/2012 11:45
Dernière modification de la notice
03/03/2018 18:18
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