In vitro assessment of the pulmonary toxicity and gastric availability of lead-rich particles from a lead recycling plant

Détails

ID Serval
serval:BIB_7323B76354FC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
In vitro assessment of the pulmonary toxicity and gastric availability of lead-rich particles from a lead recycling plant
Périodique
Environmental Science and Technology
Auteur(s)
Uzu Gaelle, Sauvain Jean-Jaques, Baeza-Squiban Armelle, Riediker Michael, Sánchez Sandoval Hohl Magdalena , Val Stephanie, Tack Karine, Denys Sébastien, Pradère Philippe, Dumat Camille
ISSN
1520-5851 (Electronic)
ISSN-L
0013-936X
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
45
Numéro
18
Pages
7888-7895
Langue
anglais
Notes
Publication types: JOURNAL ARTICLE Publication Status: ppublish
Résumé
Epidemiological studies in urban areas have linked increasing respiratory and cardiovascular pathologies with atmospheric particulate matter (PM) from anthropic activities. However, the biological fate of metal-rich PM industrial emissions in urban areas of developed countries remains understudied. Lead toxicity and bioaccessibility assessments were therefore performed on emissions from a lead recycling plant, using complementary chemical acellular tests and toxicological assays, as a function of PM size (PM(10-2.5), PM(2.5-1) and PM(1)) and origin (furnace, refining and channeled emissions). Process PM displayed differences in metal content, granulometry, and percentage of inhalable fraction as a function of their origin. Lead gastric bioaccessibility was relatively low (maximum 25%) versus previous studies; although, because of high total lead concentrations, significant metal quantities were solubilized in simulated gastrointestinal fluids. Regardless of origin, the finest PM(1) particles induced the most significant pro-inflammatory response in human bronchial epithelial cells. Moreover, this biological response correlated with pro-oxidant potential assay results, suggesting some biological predictive value for acellular tests. Pulmonary effects from lead-rich PM could be driven by thiol complexation with either lead ions or directly on the particulate surface. Finally, health concern of PM was discussed on the basis of pro-inflammatory effects, accellular test results, and PM size distribution.
Pubmed
Web of science
Création de la notice
16/08/2011 15:29
Dernière modification de la notice
03/03/2018 18:18
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