Natural killer cell receptor-repertoire and functions after induction therapy by polyclonal rabbit anti-thymocyte globulin in unsensitized kidney transplant recipients.

Détails

ID Serval
serval:BIB_731757582EE2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Natural killer cell receptor-repertoire and functions after induction therapy by polyclonal rabbit anti-thymocyte globulin in unsensitized kidney transplant recipients.
Périodique
Clinical Immunology
Auteur(s)
Hadaya K., Avila Y., Valloton L., de Rham C., Bandelier C., Ferrari-Lacraz S., Pascual M., Pantaleo G., Martin P.Y., Buhler L., Villard J.
ISSN
1521-7035[electronic], 1521-6616[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
137
Numéro
2
Pages
250-260
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Polyclonal rabbit anti-thymocyte globulin (rATG) is widely used in solid organ transplantation (SOT) as induction therapy or to treat corticosteroid-resistant rejection. In vivo, the effect of rATG on natural killer (NK) cells has not been studied. These cells are of particular relevance after SOT because classical immunosuppressive drugs do not inhibit or even can activate NK cells. A cohort of 20 recipients at low immunological risk, that had been receiving rATG as induction therapy, was analyzed for receptor repertoire, cytotoxicity and capacity of NK cells to secrete IFN-γ before kidney transplantation and at different time points thereafter. NK cells expressed fewer killer-cell immunoglobulin-like receptors (KIR), fewer activating receptors NKG2D, but more inhibitory receptor NKG2A compatible with an immature phenotype in the first 6 months post transplantation. Both cytotoxicity of NK cells and the secretion of IFN-γ were preserved over time after transplantation.
Pubmed
Web of science
Création de la notice
24/01/2011 14:12
Dernière modification de la notice
20/08/2019 14:31
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