Adiponectin as a marker of success in intracytoplasmic sperm injection/embryo transfer cycles.

Détails

ID Serval
serval:BIB_72FEED864DE9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Adiponectin as a marker of success in intracytoplasmic sperm injection/embryo transfer cycles.
Périodique
Gynecological Endocrinology
Auteur(s)
Bersinger N.A., Birkhäuser M.H., Wunder D.M.
ISSN
0951-3590 (Print)
ISSN-L
0951-3590
Statut éditorial
Publié
Date de publication
2006
Volume
22
Numéro
9
Pages
479-483
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Adiponectin (Acrp30) is an adipose tissue-derived protein whose serum concentrations, in contrast to leptin, are reported to be negatively correlated to body mass. In spite of the comparatively high circulating adiponectin concentrations, this protein has not been studied in the context of assisted reproduction to date. The aim of this preliminary project was thus to examine the potential of adiponectin to serve as a marker for fertility. We compared adiponectin levels in serum before and after controlled ovarian hyperstimulation, as well as in follicular fluid (FF), between two groups: those with successful outcome (clinical pregnancies) and those with implantation failure. In the former, adiponectin concentrations were higher than in the negative outcome group; this difference was statistically significant (p < 0.05) in serum on the day of oocyte pick-up (OPU) as well as two or three days before OPU, but not in FF or in serum at the beginning of the stimulation phase. This finding adds a new perspective to the suggested but still controversial reduction in FF leptin concentrations in the positive outcome group, and may become a useful tool for early prediction of success of in vitro fertilization treatment for a given patient.
Mots-clé
Adiponectin/blood, Adult, Biological Markers, Embryo Transfer, Estradiol/blood, Female, Humans, Leptin/blood, Pregnancy, Sperm Injections, Intracytoplasmic
Pubmed
Web of science
Création de la notice
19/03/2012 11:11
Dernière modification de la notice
03/03/2018 18:18
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