Tinea capitis dermatophytes: susceptibility to antifungal drugs tested in vitro and in vivo

Détails

ID Serval
serval:BIB_72FBEFE3AFAF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Tinea capitis dermatophytes: susceptibility to antifungal drugs tested in vitro and in vivo
Périodique
Dermatology
Auteur(s)
Mock  M., Monod  M., Baudraz-Rosselet  F., Panizzon  R. G.
ISSN
1018-8665 (Print)
Statut éditorial
Publié
Date de publication
1998
Volume
197
Numéro
4
Pages
361-7
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
BACKGROUND: Tinea capitis is a worldwide-spread infection of the scalp caused by dermatophytes and is predominantly seen in children. The clinical manifestations range from mild scaling lesions to widespread alopecia or highly inflammatory suppurating lesions. Terbinafine and itraconazole seem to be promising therapies with shorter treatment durations than griseofulvin. OBJECTIVE: The objective of the present study was to test the sensitivity of different species of dermatophytes towards terbinafine and itraconazole, and to compare the results with a retrospective study on 35 immunocompetent patients with tinea capitis who were treated with terbinafine (Lamisil(R)). METHODS: Minimal inhibitory concentrations (MIC) were measured with an agar dilution method. RESULTS: Each tested species of dermatophyte was sensitive to terbinafine and itraconazole at different concentration ranges. The MIC for terbinafine ranged from 0.005 to 0.5 microg/ml and for itraconazole from 40 to 80 microg/ml. Microsporum canis was the dermatophyte least sensitive to terbinafine. Our retrospective study showed that the cure rate was excellent for Trichophyton violaceum and T. soudanense, variable for T. mentagrophytes and poor for M. canis and M. langeronii. CONCLUSIONS: (i) Regarding the results of susceptibility tests obtained with species involved in tinea capitis, clinical efficacy is not related to MIC measured in vitro; (ii) identification of the isolated dermatophyte from tinea capitis seems to be important for choosing the appropriate treatment.
Mots-clé
Antifungal Agents/therapeutic use Arthrodermataceae/*drug effects/isolation & purification Child Child, Preschool Dermatomycoses/*drug therapy/epidemiology/microbiology Humans Itraconazole/therapeutic use Microbial Sensitivity Tests Microsporum/drug effects/isolation & purification Naphthalenes/therapeutic use Retrospective Studies Switzerland/epidemiology Tinea Capitis/*drug therapy/epidemiology/microbiology Trichophyton/drug effects/isolation & purification
Pubmed
Web of science
Création de la notice
25/01/2008 16:54
Dernière modification de la notice
20/08/2019 14:31
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