Cell locations for AQP1, AQP4 and 9 in the non-human primate brain.

Détails

Ressource 1Télécharger: BIB_72F6A4F4E7C2.P001.pdf (3682.13 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_72F6A4F4E7C2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cell locations for AQP1, AQP4 and 9 in the non-human primate brain.
Périodique
Neuroscience
Auteur(s)
Arciénega I.I., Brunet J.F., Bloch J., Badaut J.
ISSN
1873-7544[electronic], 0306-4522[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
167
Numéro
4
Pages
1103-1114
Langue
anglais
Résumé
The presence of three water channels (aquaporins, AQP), AQP1, AQP4 and AQP9 were observed in normal brain and several rodent models of brain pathologies. Little is known about AQP distribution in the primate brain and its knowledge will be useful for future testing of drugs aimed at preventing brain edema formation. We studied the expression and cellular distribution of AQP1, 4 and 9 in the non-human primate brain. The distribution of AQP4 in the non-human primate brain was observed in perivascular astrocytes, comparable to the observation made in the rodent brain. In contrast with rodent, primate AQP1 is expressed in the processes and perivascular endfeet of a subtype of astrocytes mainly located in the white matter and the glia limitans, possibly involved in water homeostasis. AQP1 was also observed in neurons innervating the pial blood vessels, suggesting a possible role in cerebral blood flow regulation. As described in rodent, AQP9 mRNA and protein were detected in astrocytes and in catecholaminergic neurons. However additional locations were observed for AQP9 in populations of neurons located in several cortical areas of primate brains. This report describes a detailed study of AQP1, 4 and 9 distributions in the non-human primate brain, which adds to the data already published in rodent brains. This relevant species differences have to be considered carefully to assess potential drugs acting on AQPs non-human primate models before entering human clinical trials.
Mots-clé
Aquaporins, Astrocyte, Water Homeostasis, Brain Edema, Energy Metabolism, Neural Stem-Cells, Creutzfeldt-Jakob-Disease, Focal Cerebral-Ischemia, Forming Schwann-Cells, Water Channel, Glial-Cells, Rat-Brain, Molecular Characterization, Catecholaminergic Neurons, Aquaporin-4 Expression
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/05/2010 9:57
Dernière modification de la notice
08/05/2019 20:23
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