Article: article from journal or magazin.
Volume expansion enhances plasma endothelin-1.
American journal of hypertension
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
We hypothesized that acute volume expansion by saline infusion triggers the release of endothelin-1. Bolus intravenous saline infusion (8 mL/min) in six groups of conscious Wistar rats and spontaneously hypertensive rats did not change mean arterial pressure or heart rate (n = 8 to 12). At 1 min after infusion, the plasma endothelin-1 level was significantly increased in Wistar rats and in spontaneously hypertensive rats by 42% and 61%, respectively (unpaired data). In 12 Wistar rats, the endothelin-1 level increased from 0.68 +/- 0.13 to 1.19 +/- 0.17 fmol/mL (mean +/- SEM, P <.0001, paired data). Thus, acute volume load by rapid saline infusion increases plasma endothelin-1 levels. Vasoconstriction induced by endothelin-1 may counteract enhanced circumferential stretch created by volume expansion.
Animals, Blood Pressure, Endothelin-1, Fluid Therapy, Heart Rate, Infusions, Intravenous, Male, Models, Animal, Rats, Rats, Inbred SHR, Rats, Wistar, Sodium Chloride, Vasoconstriction
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