Demography and natural selection have shaped genetic variation in Drosophila melanogaster: a multi-locus approach.

Détails

ID Serval
serval:BIB_72EDFBC26A86
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Demography and natural selection have shaped genetic variation in Drosophila melanogaster: a multi-locus approach.
Périodique
Genetics
Auteur(s)
Glinka S., Ometto L., Mousset S., Stephan W., De Lorenzo D.
ISSN
0016-6731
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
165
Numéro
3
Pages
1269-1278
Langue
anglais
Résumé
Demography and selection have been recognized for their important roles in shaping patterns of nucleotide variability. To investigate the relative effects of these forces in the genome of Drosophila melanogaster, we used a multi-locus scan (105 fragments) of X-linked DNA sequence variation in a putatively ancestral African and a derived European population. Surprisingly, we found evidence for a recent size expansion in the African population, i.e., a significant excess of singletons at a chromosome-wide level. In the European population, such an excess was not detected. In contrast to the African population, we found evidence for positive natural selection in the European sample: (i) a large number of loci with low levels of variation and (ii) a significant excess of derived variants at the low-variation loci that are fixed in the European sample but rare in the African population. These results are consistent with the hypothesis that the European population has experienced frequent selective sweeps in the recent past during its adaptation to new habitats. Our study shows the advantages of a genomic approach (over a locus-specific analysis) in disentangling demographic and selective forces.
Mots-clé
Animals, Drosophila melanogaster/genetics, Polymerase Chain Reaction, Polymorphism, Genetic, Recombination, Genetic, Selection (Genetics), X Chromosome
Pubmed
Web of science
Création de la notice
19/11/2007 10:33
Dernière modification de la notice
20/08/2019 14:31
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