BRAF-mutated carcinomas among thyroid nodules with prior indeterminate FNA report: a systematic review and meta-analysis.

Détails

ID Serval
serval:BIB_72E64AFE2205
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
BRAF-mutated carcinomas among thyroid nodules with prior indeterminate FNA report: a systematic review and meta-analysis.
Périodique
Clinical Endocrinology
Auteur(s)
Trimboli P., Treglia G., Condorelli E., Romanelli F., Crescenzi A., Bongiovanni M., Giovanella L.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
84
Numéro
3
Pages
315-320
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
BACKGROUND: Several molecular analyses have been investigated for risk stratification of thyroid nodules, with a particular focus on the V600E mutation of the BRAF gene [BRAF(V600E)]. To date, there is no high-level evidence supporting or refuting a role for BRAF analysis in thyroid nodules with prior indeterminate cytology. To obtain more robust evidence, we reviewed and meta-analysed data from published articles.
RESEARCH DESIGN AND METHODS: A comprehensive literature search of the PubMed/MEDLINE, Embase and Scopus databases was conducted using the terms 'BRAF', 'thyroid' and 'indeterminate'. The search was updated until March 2015, and references of the retrieved articles were also screened. Only original articles reporting BRAF mutation testing within nodules with indeterminate FNA were eligible for inclusion.
RESULTS: The literature search revealed 82 articles, of which 8 were eligible for the study. Five studies were prospective and three retrospective. The majority of authors analysed BRAF mutations in FNA samples which were classified by the British or Bethesda system. Of the initial series of studies, a pooled number of 1361 cases were achieved of which 43 were BRAF mutated. Overall, the BRAF mutation rate was 4·6% (95% CI: 1-10·8%), ranging from 0 to 22·9%. When we included only histological series, 978 thyroid nodules were found. Of these, 245 were cancers.
CONCLUSIONS: A very low rate of lesions with indeterminate cytology are BRAF mutated. Thus, the role of this biomarker to detect or exclude cancers in patients with such FNA reports is marginal and should be reconsidered in guidelines.
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/04/2015 13:57
Dernière modification de la notice
08/05/2019 20:23
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