Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken.

Détails

ID Serval
serval:BIB_72E25277DF5E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken.
Périodique
Clinical oncology
Auteur(s)
Vozenin M.C., Hendry J.H., Limoli C.L.
ISSN
1433-2981 (Electronic)
ISSN-L
0936-6555
Statut éditorial
Publié
Date de publication
07/2019
Peer-reviewed
Oui
Volume
31
Numéro
7
Pages
407-415
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
FLASH radiotherapy (FLASH-RT) is a technology that could modify the way radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of radiotherapy at dose rates several orders of magnitude higher than those currently used in routine clinical practice. This very short time of exposure leads to the striking observation of relative protection of normal tissues that are exposed to FLASH-RT as compared with conventional dose rate radiotherapy. Here we summarise the current knowledge about the FLASH effect and provide a synthesis of the observations that have been reported on various experimental animal models (mice, zebrafish, pig, cats), various organs (lung, gut, brain, skin) and by various groups across 40 years of research. We also propose possible mechanisms for the FLASH effect, as well as possible paths for clinical application.
Mots-clé
Differential effect, FLASH radiotherapy, normal tissue protection, oxygen
Pubmed
Web of science
Création de la notice
03/05/2019 16:31
Dernière modification de la notice
20/08/2019 14:31
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