pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_72DDC078615F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology.
Journal
Cancers
Author(s)
Pethő Z., Najder K., Carvalho T., McMorrow R., Todesca L.M., Rugi M., Bulk E., Chan A., Löwik CWGM, Reshkin S.J., Schwab A.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
02/09/2020
Peer-reviewed
Oui
Volume
12
Number
9
Pages
E2484
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor immunity and tumor stromal cells. The cell membrane and integral membrane proteins commonly act as important sensors and transducers of altered pH. Cell adhesion molecules and cation channels are prominent membrane proteins, the majority of which is regulated by protons. The pathophysiological consequences of proton-sensitive ion channel function in cancer, however, are scarcely considered in the literature. Thus, the main focus of this review is to highlight possible events in tumor progression and tumor immunity where the pH sensitivity of cation channels could be of great importance.
Keywords
cancer physiology, cell adhesion molecules, ion channel, membrane potential, pH homeostasis, protonation, tumor immunity, tumor microenvironment
Pubmed
Web of science
Open Access
Yes
Create date
14/09/2020 9:57
Last modification date
15/01/2021 8:10
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