Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Rôle de la MGMT et implications cliniques dans les tumeurs cérébrales [Role of MGMT and clinical applications in brain tumours]
Bulletin du cancer
Publication types: English Abstract ; Journal Article ; Review - Publication Status: ppublish
Glioblastoma multiforme is the most common and most malignant primary brain tumour with a dismal prognosis. The advent of new chemotherapies with alkylating agents crossing the blood-brain barrier, like temozolomide, have permitted to notably ameliorate the survival of a subgroup of patients. Improved outcome was associated with epigenetic silencing of the MGMT (O6-methylguanin methyltransferase) gene by promotor methylation, thereby blocking its repair capability, thus rendering the alkylating agents more effective. This particularity can be tested by methylation specific PCR on resected tumour tissue, best on fresh frozen biopsies, and allows identification of patients more susceptible to respond favourably to the treatment.
Antineoplastic Agents, Alkylating, Brain Neoplasms, DNA Methylation, DNA Modification Methylases, DNA Repair Enzymes, Drug Resistance, Neoplasm, Gene Silencing, Gene Targeting, Glioblastoma, Humans, Neoplasm Proteins, Promoter Regions, Genetic, Treatment Outcome, Tumor Suppressor Proteins
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