Individual Classification of Mild Cognitive Impairment Subtypes by Support Vector Machine Analysis of White Matter DTI.

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_72C1026C3D11
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Individual Classification of Mild Cognitive Impairment Subtypes by Support Vector Machine Analysis of White Matter DTI.
Périodique
Ajnr. American Journal of Neuroradiology
Auteur(s)
Haller S., Missonnier P., Herrmann F.R., Rodriguez C., Deiber M.P., Nguyen D., Gold G., Lovblad K.O., Giannakopoulos P.
ISSN
1936-959X (Electronic)
ISSN-L
0195-6108
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
34
Numéro
2
Pages
283-291
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND AND PURPOSE: MCI was recently subdivided into sd-aMCI, sd-fMCI, and md-aMCI. The current investigation aimed to discriminate between MCI subtypes by using DTI.
MATERIALS AND METHODS: Sixty-six prospective participants were included: 18 with sd-aMCI, 13 with sd-fMCI, and 35 with md-aMCI. Statistics included group comparisons using TBSS and individual classification using SVMs.
RESULTS: The group-level analysis revealed a decrease in FA in md-aMCI versus sd-aMCI in an extensive bilateral, right-dominant network, and a more pronounced reduction of FA in md-aMCI compared with sd-fMCI in right inferior fronto-occipital fasciculus and inferior longitudinal fasciculus. The comparison between sd-fMCI and sd-aMCI, as well as the analysis of the other diffusion parameters, yielded no significant group differences. The individual-level SVM analysis provided discrimination between the MCI subtypes with accuracies around 97%. The major limitation is the relatively small number of cases of MCI.
CONCLUSIONS: Our data show that, at the group level, the md-aMCI subgroup has the most pronounced damage in white matter integrity. Individually, SVM analysis of white matter FA provided highly accurate classification of MCI subtypes.
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/02/2013 11:41
Dernière modification de la notice
08/05/2019 20:23
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