UniProtKB amid the turmoil of plant proteomics research.

Détails

Ressource 1Télécharger: fpls-03-00270.pdf (2301.45 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_72AF5AF5D6EA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
UniProtKB amid the turmoil of plant proteomics research.
Périodique
Frontiers in Plant Science
Auteur(s)
Schneider M., Poux S.
Collaborateur(s)
Consortium Consortium
ISSN
1664-462X (Electronic)
ISSN-L
1664-462X
Statut éditorial
Publié
Date de publication
2012
Volume
3
Pages
270
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The UniProt KnowledgeBase (UniProtKB) provides a single, centralized, authoritative resource for protein sequences and functional information. The majority of its records is based on automatic translation of coding sequences (CDS) provided by submitters at the time of initial deposition to the nucleotide sequence databases (INSDC). This article will give a general overview of the current situation, with some specific illustrations extracted from our annotation of Arabidopsis and rice proteomes. More and more frequently, only the raw sequence of a complete genome is deposited to the nucleotide sequence databases and the gene model predictions and annotations are kept in separate, specialized model organism databases (MODs). In order to be able to provide the complete proteome of model organisms, UniProtKB had to implement pipelines for import of protein sequences from Ensembl and EnsemblGenomes. A single genome can be the target of several unrelated sequencing projects and the final assembly and gene model predictions may diverge quite significantly. In addition, several cultivars of the same species are often sequenced - 1001 Arabidopsis cultivars are currently under way - and the resulting proteomes are far from being identical. Therefore, one challenge for UniProtKB is to store and organize these data in a convenient way and to clearly defined reference proteomes that should be made available to users. Manual annotation is one of the landmarks of the Swiss-Prot section of UniProtKB. Besides adding functional annotation, curators are checking, and often correcting, gene model predictions. For plants, this task is limited to Arabidopsis thaliana and Oryza sativa subsp. japonica. Proteomics data providing experimental evidences confirming the existence of proteins or identifying sequence features such as post-translational modifications are also imported into UniProtKB records and the knowledgebase is cross-referenced to numerous proteomics resource.
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/01/2013 21:45
Dernière modification de la notice
16/09/2019 5:26
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