Biphasic saturations of binding proteins can be the result of a competitive inhibition of substrate fixation

Détails

ID Serval
serval:BIB_728BBD89E47A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Biphasic saturations of binding proteins can be the result of a competitive inhibition of substrate fixation
Périodique
Biochimie
Auteur(s)
Gaudin  C., Marty  B., Ragot  M., Sari  J. C., Belaich  J. P.
ISSN
0300-9084 (Print)
Statut éditorial
Publié
Date de publication
1978
Volume
60
Numéro
4
Pages
353-9
Notes
Journal Article
Résumé
A mathematical model is proposed which explains some biphasic saturations of Binding Proteins by their substrates through an effect of a competitive inhibition. The inhibitor can be the substrate itself especially when the retention phenomenon is occuring. This model has been verified with two periplasmic Binding Proteins of Escherichia coli: the Glutamine Binding Protein and the Leucine-Isoleucine-Valine Binding Protein. A significant connection is found between experimental results and the hypothesis.
Mots-clé
Binding, Competitive *Carrier Proteins/metabolism Escherichia coli/metabolism Glutamine Kinetics Mathematics Models, Chemical Oligopeptides Protein Binding
Pubmed
Web of science
Création de la notice
28/01/2008 10:31
Dernière modification de la notice
03/03/2018 18:17
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