Umbilical venous concentrations of estradiol in infants with early-onset neonatal sepsis and chorioamnionitis.

Détails

Ressource 1Demande d'une copieEtat: Supprimée
Version: Final published version
ID Serval
serval:BIB_7283A5E3529E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Umbilical venous concentrations of estradiol in infants with early-onset neonatal sepsis and chorioamnionitis.
Périodique
Journal of Neonatal-Perinatal Medicine
Auteur(s)
Schlapbach L.G., Frey S., Roger T., Calandra T., Nelle M., Aebi C., Giannoni E.
ISSN
1934-5798
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
4
Numéro
2
Pages
147-154
Langue
anglais
Résumé
Objective: Fetuses are exposed to high concentrations of estradiol due to placental production. Experimental data suggest that estradiol is an important modulator of the immune response. However, the role of estradiol in the pathogenesis of early-onset neonatal sepsis (EOS) is unknown. The purpose of this pilot study was to determine estradiol levels in umbilical venous blood of newborns with EOS or chorioamnionitis exposure.
Methods: Estradiol concentrations were measured by enzyme immunoassay in 37 newborns with EOS, 37 newborns with chorioamnionitis and 37 controls matched for gestational age and gender.
Results: Estradiol levels correlated with gestational age, birth weight, gender and mode of delivery (p < 0.05). Multivariate analysis revealed higher estradiol levels in the EOS than in the chorioamnionitis group (odds ratio 8.43, 95% CI 1.63-43.45, p = 0.01) with the highest levels in patients with proven bacteraemia (p = 0.02). No difference was found between the EOS and the control group. Exploratory analysis showed an association between lower estradiol levels and a longer duration of mechanical ventilation (n = 28, p = 0.02).
Conclusions: Umbilical venous estradiol levels were similar in EOS compared to controls. Further investigation is needed to evaluate whether high estradiol levels in infants with chorioamnionitis increases the risk of developing EOS.
Création de la notice
23/02/2012 10:23
Dernière modification de la notice
03/03/2018 18:17
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