Impact of Study Design on Reported Incidences of Acute Mountain Sickness: A Systematic Review.

Détails

ID Serval
serval:BIB_726ABD7EB531
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Compte-rendu: analyse d'une oeuvre publiée.
Collection
Publications
Titre
Impact of Study Design on Reported Incidences of Acute Mountain Sickness: A Systematic Review.
Périodique
High Altitude Medicine and Biology
Auteur(s)
Waeber B., Kayser B., Dumont L., Lysakowski C., Tramèr M.R., Elia N.
ISSN
1557-8682 (Electronic)
ISSN-L
1527-0297
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
16
Numéro
3
Pages
204-215
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
AIMS: Published incidences of acute mountain sickness (AMS) vary widely. Reasons for this variation, and predictive factors of AMS, are not well understood. We aimed to identify predictive factors that are associated with the occurrence of AMS, and to test the hypothesis that study design is an independent predictive factor of AMS incidence. We did a systematic search (Medline, bibliographies) for relevant articles in English or French, up to April 28, 2013. Studies of any design reporting on AMS incidence in humans without prophylaxis were selected. Data on incidence and potential predictive factors were extracted by two reviewers and crosschecked by four reviewers. Associations between predictive factors and AMS incidence were sought through bivariate and multivariate analyses for different study designs separately. Association between AMS incidence and study design was assessed using multiple linear regression.
RESULTS: We extracted data from 53,603 subjects from 34 randomized controlled trials, 44 cohort studies, and 33 cross-sectional studies. In randomized trials, the median of AMS incidences without prophylaxis was 60% (range, 16%-100%); mode of ascent and population were significantly associated with AMS incidence. In cohort studies, the median of AMS incidences was 51% (0%-100%); geographical location was significantly associated with AMS incidence. In cross-sectional studies, the median of AMS incidences was 32% (0%-68%); mode of ascent and maximum altitude were significantly associated with AMS incidence. In a multivariate analysis, study design (p=0.012), mode of ascent (p=0.003), maximum altitude (p<0.001), population (p=0.002), and geographical location (p<0.001) were significantly associated with AMS incidence. Age, sex, speed of ascent, duration of exposure, or history of AMS were inconsistently reported and therefore not further analyzed.
CONCLUSIONS: Reported incidences and identifiable predictive factors of AMS depend on study design.
Mots-clé
Altitude, Altitude Sickness/epidemiology, Cohort Studies, Data Accuracy, Forecasting, Humans, Incidence, Mountaineering, Research Design
Pubmed
Web of science
Création de la notice
05/10/2015 13:37
Dernière modification de la notice
03/03/2018 18:17
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