Estimation du débit de filtration glomérulaire par la formule DFG = K x T/Pcr [Estimation of glomerular filtration rate by the formula GFR = K x T/Pc].

Détails

ID Serval
serval:BIB_7268E519B474
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Estimation du débit de filtration glomérulaire par la formule DFG = K x T/Pcr [Estimation of glomerular filtration rate by the formula GFR = K x T/Pc].
Périodique
Archives de Pédiatrie
Auteur(s)
Haenggi M.H., Pelet J., Guignard J.P.
ISSN
0929-693X (Print)
ISSN-L
0929-693X
Statut éditorial
Publié
Date de publication
1999
Volume
6
Numéro
2
Pages
165-172
Langue
français
Notes
Publication types: Comparative Study ; English Abstract ; Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND: Creatinine clearance is the most common method used to assess glomerular filtration rate (GFR). In children, GFR can also be estimated without urine collection, using the formula GFR (mL/min x 1.73 m2) = K x height [cm]/Pcr [mumol/L]), where Pcr represents the plasma creatinine concentration. K is usually calculated using creatinine clearance (Ccr) as an index of GFR. The aim of the present study was to evaluate the reliability of the formula, using the standard UV/P inulin clearance to calculate K.
METHODS: Clearance data obtained in 200 patients (1 month to 23 years) during the years 1988-1994 were used to calculate the factor K as a function of age. Forty-four additional patients were studied prospectively in conditions of either hydropenia or water diuresis in order to evaluate the possible variation of K as a function of urine flow rate.
RESULTS: When GFR was estimated by the standard inulin clearance, the calculated values of K was 39 (infants less than 6 months), 44 (1-2 years) and 47 (2-12 years). The correlation between the values of GFR, as estimated by the formula, and the values measured by the standard clearance of inulin was highly significant; the scatter of individual values was however substantial. When K was calculated using Ccr, the formula overestimated Cin at all urine flow rates. When calculated from Ccr, K varied as a function of urine flow rate (K = 50 at urine flow rates of 3.5 and K = 64 at urine flow rates of 8.5 mL/min x 1.73 m2). When calculated from Cin, in the same conditions, K remained constant with a value of 50.
CONCLUSIONS: The formula GFR = K x H/Pcr can be used to estimate GFR. The scatter of values precludes however the use of the formula to estimate GFR in pathophysiological studies. The formula should only be used when K is calculated from Cin, and the plasma creatinine concentration is measured in well defined conditions of hydration.
Mots-clé
Adolescent, Adult, Age Factors, Child, Child, Preschool, Creatinine/blood, Creatinine/urine, Evaluation Studies as Topic, Glomerular Filtration Rate, Humans, Infant, Inulin/diagnostic use
Pubmed
Web of science
Création de la notice
04/02/2010 12:02
Dernière modification de la notice
02/05/2018 6:26
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