Dietary vitamin D and cancers of the oral cavity and esophagus.

Détails

ID Serval
serval:BIB_7256230DC865
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dietary vitamin D and cancers of the oral cavity and esophagus.
Périodique
Annals of Oncology
Auteur(s)
Lipworth Loren, Rossi Marta, McLaughlin Joseph K., Negri Eva, Talamini Renato, Levi Fabio, Franceschi Silvia, La Vecchia Carlo
ISSN
1569-8041[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
20
Numéro
9
Pages
1576-1581
Langue
anglais
Résumé
BACKGROUND: Data on the association between vitamin D and upper digestive tract neoplasms are limited. METHODS: In two case-control studies in Italy, we examined the relation between dietary vitamin D intake and squamous cell carcinoma of the esophagus (SCCE; 304 cases) and oral/pharyngeal cancer (804 cases). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by multiple logistic regression. RESULTS: Adjusted ORs for SCCE and oral/pharyngeal cancer were 0.58 (95% CI 0.39-0.86) and 0.76 (95% CI 0.60-0.94), respectively, for the highest tertile of vitamin D intake. Using a reference group of those in the highest tertile of vitamin D who were never/former smokers, ORs were 8.7 (95% CI 4.1-18.7) for SCCE and 10.4 (95% CI 6.9-15.5) for oral/pharyngeal cancer among heavy smokers in the lowest vitamin D tertile; similarly, compared with those in the highest tertile of vitamin D who drank <3 alcoholic drinks/day, corresponding ORs were 41.9 (95% CI 13.7-128.6) for SCCE and 8.5 (95% CI 5.7-12.5) for oral/pharyngeal cancer, among heavy alcohol drinkers in the lowest vitamin D tertile. CONCLUSION: We observed inverse associations between dietary vitamin D intake and risk of SCCE and, perhaps, oral/pharyngeal cancer, which were most pronounced among heavy current smokers and heavy consumers of alcohol.
Mots-clé
Adult, Aged, Alcohol Drinking/adverse effects, Case-Control Studies, Diet, Esophageal Neoplasms/epidemiology, Female, Humans, Incidence, Male, Middle Aged, Mouth Neoplasms/epidemiology, Odds Ratio, Smoking/adverse effects, Vitamin D/administration & dosage, Vitamins/administration & dosage
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/02/2010 17:37
Dernière modification de la notice
08/05/2019 20:21
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