Nouvelles thérapies pour les maladies osseuses de l'enfant [New therapies for children affected by bone diseases].

Détails

ID Serval
serval:BIB_7253090BCD83
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Nouvelles thérapies pour les maladies osseuses de l'enfant [New therapies for children affected by bone diseases].
Périodique
Revue Médicale Suisse
Auteur(s)
Ballhausen D., Dépraz N.G., Kern I., Unger S., Bonafé L.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
2012
Volume
8
Numéro
329
Pages
398-402
Langue
français
Notes
Publication types: English Abstract ; Journal Article Publication Status: ppublish
Résumé
Considerable progress has been achieved in recent years in treating children affected by bone diseases. Advances in the understanding of the molecular pathophysiology of genetic bone diseases have led to the development of enzyme replacement therapies for various lysosomal storage diseases, following the breakthrough initiated in treating Gaucher disease. Clinical studies are underway with tailored molecules correcting bone fragility and alleviating chronic bone pain and other manifestations of hypophosphatasia, or promoting growth of long bones in achondroplasia patients. We further report our very encouraging experience with intravenous bisphosphonate treatment in children suffering from secondary osteopenia and the high prevalence of calcium and vitamin D deficits in these severely disabled children.
Mots-clé
Bone Diseases/drug therapy, Child, Humans
Pubmed
Création de la notice
06/06/2012 19:06
Dernière modification de la notice
03/03/2018 18:17
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