A monoclonal antibody specific for the carboxy-terminus of angiotensin II

Détails

ID Serval
serval:BIB_723C950F5818
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A monoclonal antibody specific for the carboxy-terminus of angiotensin II
Périodique
Hybridoma
Auteur(s)
Nussberger  J., Mudgett-Hunter  M., Matsueda  G., Haber  E.
ISSN
0272-457X (Print)
Statut éditorial
Publié
Date de publication
1984
Volume
3
Numéro
4
Pages
373-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Winter
Résumé
A monoclonal antibody specific for the carboxy-terminus of angiotensin II was produced from the somatic cell fusion between SP2/0 myeloma cells and spleen cells from CAF/J mice immunized with angiotensin II selectively coupled to thyroglobulin. The subcloned line D5-7R2 was augmented in the ascites form and shown to be specific for angiotensin II (octapeptide) and shorter angiotensin peptides. This antibody, however, did not cross-react with angiotensin I (decapeptide). This selectivity will be important in clinical assays that measure angiotensin II in the presence of angiotensin I.
Mots-clé
Angiotensin II/*immunology Animals Antibodies, Monoclonal/*immunology Antibody Specificity Cross Reactions Hybridomas/immunology Immunization Mice Mice, Inbred Strains/immunology Peptide Fragments/immunology
Pubmed
Web of science
Création de la notice
05/03/2008 17:41
Dernière modification de la notice
03/03/2018 18:16
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