FMRP and its target RNAs: fishing for the specificity.

Détails

ID Serval
serval:BIB_72330E11E8AF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
FMRP and its target RNAs: fishing for the specificity.
Périodique
Neuroreport
Auteur(s)
Veneri M., Zalfa F., Bagni C.
ISSN
0959-4965 (Print)
ISSN-L
0959-4965
Statut éditorial
Publié
Date de publication
15/11/2004
Volume
15
Numéro
16
Pages
2447-2450
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Learning and memory difficulties observed in patients with fragile X syndrome, as well as in a mouse model for the syndrome, are partially due to impaired translational regulation of neuronal mRNAs encoding key molecules for the synaptic structure and function. There has been intense interest in characterizing the mRNAs that are regulated by the fragile X mental retardation protein (FMRP) in the neuronal cell. A large number of candidate FMRP-interacting mRNAs has been identified over the last few years and three models have been described so far to explain the specificity of these interactions. Here, we report our vision on how they could work in the same and/or in different pathways and suggest that the three mechanisms may not be mutually exclusive.

Mots-clé
Animals, Fragile X Mental Retardation Protein, Humans, MicroRNAs/metabolism, Models, Molecular, Nerve Tissue Proteins/metabolism, RNA, Messenger/metabolism, RNA-Binding Proteins/metabolism
Pubmed
Création de la notice
06/03/2017 18:23
Dernière modification de la notice
03/03/2018 18:16
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