Histone H1 regulates chromatin condensation in Leishmania parasites.

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Serval ID
serval:BIB_721FF45AC3A7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Histone H1 regulates chromatin condensation in Leishmania parasites.
Journal
Experimental Parasitology
Author(s)
Masina S., Zangger H., Rivier D., Fasel N.
ISSN
0014-4894 (Print)
ISSN-L
0014-4894
Publication state
Published
Issued date
2007
Volume
116
Number
1
Pages
83-87
Language
english
Abstract
We investigated the functional role of the Leishmania histone H1 and demonstrate for the first time that addition of histone H1 has a strong effect on microccocal digestion, chromatin condensation of parasite nuclei and that its overexpression can modulate parasite infectivity in vivo.
Keywords
Animals, Cell Line, Chromatin/metabolism, Gene Expression, Histones/genetics, Histones/physiology, Leishmania major/chemistry, Leishmania major/pathogenicity, Leishmaniasis, Cutaneous/parasitology, Macrophages/parasitology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Signal Transduction, Transfection, Virulence
OAI-PMH
oai:serval.unil.ch:BIB_721FF45AC3A7
DOI
10.1016/j.exppara.2006.11.002
Pubmed
17207482
Web of science
000246219200011
Create date
24/01/2008 15:02
Last modification date
19/08/2020 5:22
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