Apnea-like suppression of respiratory motion: First evaluation in radiotherapy.

Détails

ID Serval
serval:BIB_721A2FE5C894
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Apnea-like suppression of respiratory motion: First evaluation in radiotherapy.
Périodique
Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology
Auteur(s)
Péguret N., Ozsahin M., Zeverino M., Belmondo B., Durham A.D., Lovis A., Simons J., Long O., Duclos F., Prior J., Denys A., Beigelman C., Sozzi W.J., Grant K., Gautier-Dechaud V., Peters S., Vienne M., Moeckli R., Bourhis J.
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
118
Numéro
2
Pages
220-226
Langue
anglais
Résumé
BACKGROUND AND PURPOSE: Compensation for respiratory motion is needed while administering radiotherapy (RT) to tumors that are moving with respiration to reduce the amount of irradiated normal tissues and potentially decrease radiation-induced collateral damages. The purpose of this study was to test a new ventilation system designed to induce apnea-like suppression of respiratory motion and allow long enough breath hold durations to deliver complex RT.
MATERIAL AND METHODS: The High Frequency Percussive Ventilation system was initially tested in a series of 10 volunteers and found to be well tolerated, allowing a median breath hold duration of 11.6min (range 3.9-16.5min). An evaluation of this system was subsequently performed in 4 patients eligible for adjuvant breast 3D conformal RT, for lung stereotactic body RT (SBRT), lung volumetric modulated arc therapy (VMAT), and VMAT for palliative pleural metastases.
RESULTS: When compared to free breathing (FB) and maximal inspiration (MI) gating, this Percussion Assisted RT (PART) offered favorable dose distribution profiles in 3 out of the 4 patients tested. PART was applied in these 3 patients with good tolerance, without breaks during the "beam on time period" throughout the overall courses of RT. The mean duration of the apnea-like breath hold that was necessary for delivering all the RT fractions was 7.61min (SD=2.3).
CONCLUSIONS: This first clinical implementation of PART was found to be feasible, tolerable and offers new opportunities in the field of RT for suppressing respiratory motion.
Pubmed
Web of science
Création de la notice
17/03/2016 17:27
Dernière modification de la notice
20/08/2019 14:30
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