Expression Evolution of Ancestral XY Gametologs across All Major Groups of Placental Mammals.
Details
Serval ID
serval:BIB_720BBFDCDE8D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Expression Evolution of Ancestral XY Gametologs across All Major Groups of Placental Mammals.
Journal
Genome biology and evolution
ISSN
1759-6653 (Electronic)
ISSN-L
1759-6653
Publication state
Published
Issued date
03/11/2020
Peer-reviewed
Oui
Volume
12
Number
11
Pages
2015-2028
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Placental mammals present 180 million-year-old Y chromosomes that have retained a handful of dosage-sensitive genes. However, the expression evolution of Y-linked genes across placental groups has remained largely unexplored. Here, we expanded the number of Y gametolog sequences by analyzing ten additional species from previously unexplored groups. We detected seven remarkably conserved genes across 25 placental species with known Y repertoires. We then used RNA-seq data from 17 placental mammals to unveil the expression evolution of XY gametologs. We found that Y gametologs followed, on average, a 3-fold expression loss and that X gametologs also experienced some expression reduction, particularly in primates. Y gametologs gained testis specificity through an accelerated expression decay in somatic tissues. Moreover, despite the substantial expression decay of Y genes, the combined expression of XY gametologs in males is higher than that of both X gametologs in females. Finally, our work describes several features of the Y chromosome in the last common mammalian ancestor.
Keywords
Animals, Base Sequence, Biological Evolution, Conserved Sequence, Dosage Compensation, Genetic, Eutheria/genetics, Female, Gene Expression, Genes, X-Linked, Genes, Y-Linked, Humans, Male, Organ Specificity, Y chromosome, dosage compensation mechanisms, gene expression levels, placental mammals, sex chromosomes
Pubmed
Web of science
Open Access
Yes
Create date
28/08/2020 8:21
Last modification date
08/08/2024 7:35