Real-time fluorescence imaging in intraoperative decision making for cancer surgery.

Details

Serval ID
serval:BIB_720740D918FD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Real-time fluorescence imaging in intraoperative decision making for cancer surgery.
Journal
The Lancet. Oncology
Author(s)
Lauwerends L.J., van Driel PBAA, Baatenburg de Jong R.J., Hardillo JAU, Koljenovic S., Puppels G., Mezzanotte L., Löwik CWGM, Rosenthal E.L., Vahrmeijer A.L., Keereweer S.
ISSN
1474-5488 (Electronic)
ISSN-L
1470-2045
Publication state
Published
Issued date
05/2021
Peer-reviewed
Oui
Volume
22
Number
5
Pages
e186-e195
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Fluorescence-guided surgery is an intraoperative optical imaging method that provides surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 clinical trials, evaluation of fluorescence-guided surgery is primarily focused on its diagnostic performance, although the corresponding outcome variables do not inform about the added clinical benefit of fluorescence-guided surgery and are challenging to assess objectively. Nonetheless, the effect of fluorescence-guided surgery on intraoperative decision making is the most objective outcome measurement to assess the clinical value of this imaging method. In this Review, we explore the study designs of existing trials of fluorescence-guided surgery that allow us to extract information on potential changes in intraoperative decision making, such as additional or more conservative resections. On the basis of this analysis, we offer recommendations on how to report changes in intraoperative decision making that result from fluorescence imaging, which is of utmost importance for the widespread clinical implementation of fluorescence-guided surgery.
Keywords
Clinical Trials as Topic, Decision Making, Fluorescence, Humans, Intraoperative Period, Neoplasms/surgery, Optical Imaging/methods, Research Design, Surgery, Computer-Assisted/methods
Pubmed
Web of science
Create date
05/04/2021 9:28
Last modification date
28/09/2021 5:57
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