Abnormal T lymphocyte development induced by targeted overexpression of IkappaB alpha.

Détails

ID Serval
serval:BIB_71FEA4F26724
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Abnormal T lymphocyte development induced by targeted overexpression of IkappaB alpha.
Périodique
Journal of Immunology
Auteur(s)
Esslinger C.W., Wilson A., Sordat B., Beermann F., Jongeneel C.V.
ISSN
0022-1767[print], 0022-1767[linking]
Statut éditorial
Publié
Date de publication
06/1997
Volume
158
Numéro
11
Pages
5075-5078
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
A role in thymic maturation for factors of the NF-kappaB family has long been suspected, but not yet proven. Transgenic mice with a lymphocyte-specific defect in NF-kappaB activation were produced by targeted expression of human IkappaB alpha. The thymic cellularity of these mice was significantly decreased. The proportion of mature, TCRhigh thymocytes of the alphabeta lineage was reduced, and the remaining TCRhigh population contained an unusually high proportion of double-positive cells. This defect in maturation resulted in a transgene dose-dependent reduction in peripheral T lymphocytes, with the CD8 lineage being more severely affected. These data provide direct evidence for the involvement of NF-kappaB/Rel family proteins in late stages of T lymphocyte development, coincident with positive and negative selection.
Mots-clé
Animals, DNA-Binding Proteins/genetics, DNA-Binding Proteins/immunology, Flow Cytometry, Gene Expression Regulation, Gene Transfer Techniques, Humans, I-kappa B Proteins, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, NF-kappa B/genetics, NF-kappa B/immunology, T-Lymphocyte Subsets/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 15:39
Dernière modification de la notice
20/08/2019 14:30
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