The role of Notch signaling during hematopoietic lineage commitment.

Détails

ID Serval
serval:BIB_71FC6A0C5595
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The role of Notch signaling during hematopoietic lineage commitment.
Périodique
Immunological reviews
Auteur(s)
Radtke F., Wilson A., Ernst B., MacDonald H.R.
ISSN
0105-2896
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
187
Pages
65-74
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Over the last few years a vast amount of progress has been made in identifying mechanisms controlling lineage commitment and plasticity of hematopoietic precursors to different lymphoid or myeloid lineages. This has been due largely to the ability to identify and isolate rare cell populations in order to investigate their developmental potential, together with the development of inducible and/or tissue specific targeting technology. One family of proteins that has been postulated to be involved in hematopoietic stem cell maintenance as well as in multiple commitment processes during T cell development is the Notch receptors and their ligands. In this review we will summarize recent findings and controversies regarding the role of Notch signaling in the myeloid and lymphoid systems.
Mots-clé
Animals, Cell Differentiation, Cell Lineage, Hematopoiesis, Humans, Lymphocytes/cytology, Lymphocytes/metabolism, Membrane Proteins/metabolism, Myeloid Cells/cytology, Myeloid Cells/metabolism, Receptors, Notch, Signal Transduction
Pubmed
Web of science
Création de la notice
28/01/2008 11:39
Dernière modification de la notice
20/08/2019 14:30
Données d'usage