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Identification of a new oncofoetal antigen associated with several types of human carcinomas.
In experimental animals, oncofoetal antigens1 have been found to be associated with both chemical-2 and virus-induced tumours3. In man the two best known oncofoetal antigens are the α-foetoprotein (AFP) described by both Abelev4 and Tatarinov5 and the carcinoembryonic antigen (CEA) of the human digestive system identified by Gold and Freedman6. We describe here a different human oncofoetal antigen, common to several types of carcinomas and various foetal organs. This antigen has been identified by rabbit antisera raised against semipurified fractions of colon carcinoma soluble extracts. Because of its β-immunoelectrophoretic mobility, this antigen will be referred to as β-oncofoetal antigen (BOFA).
Antigens, Neoplasm/analysis, Brain Neoplasms/immunology, Breast Neoplasms/immunology, Carcinoma/immunology, Cell Line, Colonic Neoplasms/immunology, Fetus/immunology, Humans, Kidney Neoplasms/immunology, Liver Neoplasms/immunology, Lung Neoplasms/immunology, Melanoma/immunology, Neoplasm Metastasis, Pancreatic Neoplasms/immunology, Skin Neoplasms/immunology
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