Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants.

Détails

ID Serval
serval:BIB_7177FD7DE86E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants.
Périodique
Ajnr. American Journal of Neuroradiology
Auteur(s)
Schneider J., Kober T., Bickle Graz M., Meuli R., Hüppi P.S., Hagmann P., Truttmann A.C.
ISSN
1936-959X (Electronic)
ISSN-L
0195-6108
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
37
Numéro
1
Pages
155-162
Langue
anglais
Résumé
BACKGROUND AND PURPOSE: The alteration of brain maturation in preterm infants contributes to neurodevelopmental disabilities during childhood. Serial imaging allows understanding of the mechanisms leading to dysmaturation in the preterm brain. The purpose of the present study was to provide reference quantitative MR imaging measures across time in preterm infants, by using ADC, fractional anisotropy, and T1 maps obtained by using the magnetization-prepared dual rapid acquisition of gradient echo technique.
MATERIALS AND METHODS: We included preterm neonates born at <30 weeks of gestational age without major brain lesions on early cranial sonography and performed 3 MRIs (3T) from birth to term-equivalent age. Multiple measurements (ADC, fractional anisotropy, and T1 relaxation) were performed on each examination in 12 defined white and gray matter ROIs.
RESULTS: We acquired 107 MRIs (35 early, 33 intermediary, and 39 at term-equivalent age) in 39 cerebral low-risk preterm infants. Measures of T1 relaxation time showed a gradual and significant decrease with time in a region- and hemispheric-specific manner. ADC values showed a similar decline with time, but with more variability than T1 relaxation. An increase of fractional anisotropy values was observed in WM regions and inversely a decrease in the cortex.
CONCLUSIONS: The gradual change with time reflects the progressive maturation of the cerebral microstructure in white and gray matter. Our study provides reference trajectories from 25 to 40 weeks of gestation of T1 relaxation, ADC, and fractional anisotropy values in low-risk preterm infants. We speculate that deviation thereof might reflect disturbed cerebral maturation; the correlation of this disturbed maturation with neurodevelopmental outcome remains to be addressed.
Mots-clé
Anisotropy, Brain/growth & development, Developmental Disabilities/diagnosis, Female, Gestational Age, Humans, Image Processing, Computer-Assisted/methods, Infant, Infant, Newborn, Infant, Premature/growth & development, Magnetic Resonance Imaging/methods, Male, Reference Values, Statistics as Topic
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/10/2015 14:53
Dernière modification de la notice
20/08/2019 14:29
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