Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.

Détails

ID Serval
serval:BIB_716FC2928A80
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.
Périodique
Cell
Auteur(s)
Sinturel F., Gerber A., Mauvoisin D., Wang J., Gatfield D., Stubblefield J.J., Green C.B., Gachon F., Schibler U.
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
169
Numéro
4
Pages
651-663.e14
Langue
anglais
Résumé
The liver plays a pivotal role in metabolism and xenobiotic detoxification, processes that must be particularly efficient when animals are active and feed. A major question is how the liver adapts to these diurnal changes in physiology. Here, we show that, in mice, liver mass, hepatocyte size, and protein levels follow a daily rhythm, whose amplitude depends on both feeding-fasting and light-dark cycles. Correlative evidence suggests that the daily oscillation in global protein accumulation depends on a similar fluctuation in ribosome number. Whereas rRNA genes are transcribed at similar rates throughout the day, some newly synthesized rRNAs are polyadenylated and degraded in the nucleus in a robustly diurnal fashion with a phase opposite to that of ribosomal protein synthesis. Based on studies with cultured fibroblasts, we propose that rRNAs not packaged into complete ribosomal subunits are polyadenylated by the poly(A) polymerase PAPD5 and degraded by the nuclear exosome.

Pubmed
Web of science
Open Access
Oui
Création de la notice
08/05/2017 14:14
Dernière modification de la notice
20/08/2019 15:29
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