Article: article from journal or magazin.
Human natural killer cells enhance a mixed leukocyte reaction.
Journal of Leukocyte Biology
Natural killer cells (NK) have been reported to down-regulate the initiation of T cell responses in animal models. In the current study, highly purified CD16+ human NK cells were obtained by cell sorting and their effect on the stimulation of allogeneic T cells (MLR) determined. NK cells did not directly stimulate T cell proliferation. However, when added to a population of loosely adherent mononuclear cells (LAM), NK enhanced the ability of these accessory cells to stimulate T proliferation. This effect was not reproduced by the addition of sorted CD5 + T cells, sorted CD16- cells, or control lymphocytes to the MLR. The effect of NK on the MLR was not restricted by class II antigens and was similar to the effect of adding IL-1 to MLR cultures. These results demonstrate that human NK cells are capable of enhancing a T cell response.
Antigen-Presenting Cells/immunology, Cell Separation, Humans, Interleukin-1/biosynthesis, Interleukin-1/pharmacology, Killer Cells, Natural/immunology, Lymphocyte Activation, Lymphocyte Culture Test, Mixed, Major Histocompatibility Complex, T-Lymphocytes/immunology
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