Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI.

Détails

ID Serval
serval:BIB_70EE80048D23
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI.
Périodique
Magnetic resonance in medicine
Auteur(s)
Schär M., Soleimanifard S., Bonanno G., Yerly J., Hays A.G., Weiss R.G.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
01/2019
Peer-reviewed
Oui
Volume
81
Numéro
1
Pages
291-302
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Coronary endothelial function (CEF) reflects vascular health and conventional invasive CEF measures predict cardiovascular events. MRI can now noninvasively measure CEF by quantifying coronary artery cross-sectional area changes in response to isometric handgrip exercise, an endothelial-dependent stressor. Area changes (10 to 20% in healthy; 2 to -12% in impaired vessels) are only a few imaging voxels because of MRI's limited spatial resolution. Here, with numerical simulations and phantom studies, we test whether Fourier interpolation enables sub-pixel area measurement precision and determine the smallest detectable area change using spiral MRI.
In vivo coronary SNR with the currently used CEF protocol at 3T was measured in 7 subjects for subsequent in vitro work. Area measurements of circular vessels were simulated by varying partial volume, vessel diameter, voxel size, SNR, and Fourier interpolation factor. A phantom with precision-drilled holes (diameters 3-3.42 mm) was imaged 10 times with the current CEF protocol (voxel size, Δx = 0.89 mm) and a high-resolution protocol (Δx = 0.6 mm) to determine precision, accuracy, and the smallest detectable area changes.
In vivo coronary SNR ranged from 30-76. Eight-fold Fourier interpolation improved area measurement precision by a factor 6.5 and 4.9 in the simulations and phantom scans, respectively. The current CEF protocol can detect mean area changes of 4-5% for SNR above 30, and 3-3.5% for SNR above 40 with a higher-resolution protocol.
Current CEF spiral MRI with in vivo SNR allows detection of a 4-5% area change and Fourier interpolation improves precision several-fold to sub-voxel dimensions.
Mots-clé
Fourier interpolation, MRI, coronary endothelial function, cross-sectional area measurement, vasodilation, spiral
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/07/2018 12:40
Dernière modification de la notice
20/08/2019 15:29
Données d'usage