Major role for neuronal death during brain development: refinement of topographical connections.

Details

Serval ID
serval:BIB_70D0C20D5E58
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Major role for neuronal death during brain development: refinement of topographical connections.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Catsicas S., Thanos S., Clarke P.G.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Publication state
Published
Issued date
1987
Volume
84
Number
22
Pages
8165-8168
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The precision of the topographic projection from the isthmo-optic nucleus (ION) to the retina has been examined in chicken embryos and chicks by the retrograde transport of a fluorescent carbocyanine dye from restricted retinal sites. At all ages, the labeled neurons are most numerous in the topographically appropriate part of the ION, but in younger embryos up to 49% of them are found outside this region. The distribution of these "aberrantly" projecting neurons is variable, but they generally occur throughout the entire ION. They all die during the ION's period of neuronal death, accounting for most of the 60% cell loss that then occurs. We therefore suggest that a major role of neuronal death during brain development is to reduce the imprecision of neuronal connections.
Keywords
Animals, Brain/cytology, Brain/embryology, Cell Survival, Chick Embryo, Chickens, Neurons/cytology, Retina/embryology, Retina/growth & development, Visual Pathways/embryology, Visual Pathways/growth & development
Pubmed
Web of science
Open Access
Yes
Create date
20/01/2008 17:49
Last modification date
20/08/2019 14:29
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