Topographic organization of V1 projections through the corpus callosum in humans.

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Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Topographic organization of V1 projections through the corpus callosum in humans.
Journal
Neuroimage
Author(s)
Saenz M., Fine I.
ISSN
1095-9572[electronic], 1053-8119[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
52
Number
4
Pages
1224-1229
Language
english
Abstract
The visual cortex in each hemisphere is linked to the opposite hemisphere by axonal projections that pass through the splenium of the corpus callosum. Visual-callosal connections in humans and macaques are found along the V1/V2 border where the vertical meridian is represented. Here we identify the topography of V1 vertical midline projections through the splenium within six human subjects with normal vision using diffusion-weighted MR imaging and probabilistic diffusion tractography. Tractography seed points within the splenium were classified according to their estimated connectivity profiles to topographic subregions of V1, as defined by functional retinotopic mapping. First, we report a ventral-dorsal mapping within the splenium with fibers from ventral V1 (representing the upper visual field) projecting to the inferior-anterior corner of the splenium and fibers from dorsal V1 (representing the lower visual field) projecting to the superior-posterior end. Second, we also report an eccentricity gradient of projections from foveal-to-peripheral V1 subregions running in the anterior-superior to posterior-inferior direction, orthogonal to the dorsal-ventral mapping. These results confirm and add to a previous diffusion MRI study (Dougherty et al., 2005) which identified a dorsal/ventral mapping of human splenial fibers. These findings yield a more detailed view of the structural organization of the splenium than previously reported and offer new opportunities to study structural plasticity in the visual system.
Keywords
primary visual-cortex, living human brain, macaque monkey, rhesus-monkey, white-matter, diffusion tractography, connections, areas, cat, mri
Pubmed
Web of science
Open Access
Yes
Create date
01/09/2010 13:03
Last modification date
20/08/2019 14:29
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