Article: article from journal or magazin.
Dynamic optical breast imaging: a novel technique to detect and characterize tumor vessels
Eur J Radiol
1872-7727 (Electronic)0720-048X (Linking)
Fournier, Laure SVanel, DanielAthanasiou, AlexandraGatzemeier, WolfgangMasuykov, I VPadhani, Anwar RDromain, ClarisseGaletti, KenSigal, RobertCosta, AlbertoBalleyguier, CorinneengResearch Support, Non-U.S. Gov'tIreland2008/10/03 09:00Eur J Radiol. 2009 Jan;69(1):43-9. doi: 10.1016/j.ejrad.2008.07.038. Epub 2008 Sep 30.
PURPOSE: To prospectively determine the diagnostic accuracy of optical absorption imaging in patients with Breast Imaging Reporting and Data System (BI-RADS) 3-5 breast lesions. MATERIALS AND METHODS: Forty-six patients with BI-RADS classification 3 (11%), 4 (44%) or 5 (44%) lesions, underwent a novel optical imaging examination using red light to illuminate the breast. Pressure was applied on the breast, and time-dependent curves of light absorption were recorded. Curves that consistently increased or decreased over time were classified as suspicious for malignancy. All patients underwent a core or surgical biopsy. RESULTS: Optical mammography showed a statistical difference in numbers of suspect pixels between benign (N=12) and malignant (N=35) lesions (respectively 1325 vs. 3170, P=0.002). In this population, optical imaging had a sensitivity of 74%, specificity of 92%, and diagnostic accuracy of 79%. The optical signal did not vary according to any other parameter including breast size or density, age, hormonal status or histological type of lesions. CONCLUSION: Optical imaging is a low-cost, non-invasive technique, yielding physiological information dependent on breast blood volume and oxygenation. It appears to have a good potential for discriminating benign from malignant lesions. Further studies are warranted to define its potential role in breast cancer imaging.
Adolescent, Adult, Aged, Aged, 80 and over, *Algorithms, Breast Neoplasms/*blood supply/*pathology, Female, Humans, Image Enhancement/methods, Image Interpretation, Computer-Assisted/*methods, Lighting/*methods, Male, Middle Aged, Neovascularization, Pathologic/*pathology, Photography/*methods, Reproducibility of Results, Sensitivity and Specificity, Young Adult
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