Reconciliation of metabolites and biochemical reactions for metabolic networks.

Détails

Ressource 1Télécharger: 23172809_BIB_6FC073DA2CF5.pdf (1203.26 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_6FC073DA2CF5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reconciliation of metabolites and biochemical reactions for metabolic networks.
Périodique
Briefings in Bioinformatics
Auteur(s)
Bernard T., Bridge A., Morgat A., Moretti S., Xenarios I., Pagni M.
ISSN
1477-4054 (Electronic)
ISSN-L
1467-5463
Statut éditorial
Publié
Date de publication
2014
Volume
15
Numéro
1
Pages
123-135
Langue
anglais
Résumé
Genome-scale metabolic network reconstructions are now routinely used in the study of metabolic pathways, their evolution and design. The development of such reconstructions involves the integration of information on reactions and metabolites from the scientific literature as well as public databases and existing genome-scale metabolic models. The reconciliation of discrepancies between data from these sources generally requires significant manual curation, which constitutes a major obstacle in efforts to develop and apply genome-scale metabolic network reconstructions. In this work, we discuss some of the major difficulties encountered in the mapping and reconciliation of metabolic resources and review three recent initiatives that aim to accelerate this process, namely BKM-react, MetRxn and MNXref (presented in this article). Each of these resources provides a pre-compiled reconciliation of many of the most commonly used metabolic resources. By reducing the time required for manual curation of metabolite and reaction discrepancies, these resources aim to accelerate the development and application of high-quality genome-scale metabolic network reconstructions and models.
Mots-clé
data integration, data interoperability, metabolic resources, metabolic networks, cheminformatics
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/03/2014 11:28
Dernière modification de la notice
08/05/2019 20:13
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