Clinical implications of Mycobacterium kansasii species heterogeneity: Swiss National Survey

Details

Serval ID
serval:BIB_6F22F524C924
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical implications of Mycobacterium kansasii species heterogeneity: Swiss National Survey
Journal
Journal of Clinical Microbiology
Author(s)
Taillard  C., Greub  G., Weber  R., Pfyffer  G. E., Bodmer  T., Zimmerli  S., Frei  R., Bassetti  S., Rohner  P., Piffaretti  J. C., Bernasconi  E., Bille  J., Telenti  A., Prod'hom  G.
ISSN
0095-1137 (Print)
Publication state
Published
Issued date
03/2003
Volume
41
Number
3
Pages
1240-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
Several subtypes of Mycobacterium kansasii have been described, but their respective pathogenic roles are not clear. This study investigated the distribution of subtypes and the pathogenicity of M. kansasii strains (n = 191) isolated in Switzerland between 1991 and 1997. Demographic, clinical, and microbiological information was recorded from clinical files. Patients were classified as having an infection according to the criteria of the American Thoracic Society. Subtypes were defined by PCR-restriction enzyme analysis of the hsp65 gene. Subtype 1 comprised 67% of the isolates (n = 128), while subtypes 2 and 3 comprised 21% (n = 40) and 8% (n = 15), respectively. Other subtypes (subtypes 4 and 6 and a new subtype, 7) were recovered from only 4% of patients (n = 8). M. kansasii subtype 1 was considered pathogenic in 81% of patients, while M. kansasii subtype 2 was considered pathogenic in 67% of patients and other subtypes were considered pathogenic in 6% of patients. The majority of patients with M. kansasii subtype 2 were immunocompromised due to the use of corticosteroids (21% of patients) or coinfection with HIV (62.5% of patients). Subtyping M. kansasii may improve clinical management by distinguishing pathogenic from nonpathogenic subtypes.
Keywords
Adult Data Collection Female Humans Male Middle Aged Mycobacterium kansasii/classification/*genetics/pathogenicity Sweden *Variation (Genetics)
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:45
Last modification date
20/08/2019 14:28
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