Comparison of accelerated T1-weighted whole-brain structural-imaging protocols.

Détails

ID Serval
serval:BIB_6F22567501F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of accelerated T1-weighted whole-brain structural-imaging protocols.
Périodique
Neuroimage
Auteur(s)
Falkovskiy P., Brenner D., Feiweier T., Kannengiesser S., Maréchal B., Kober T., Roche A., Thostenson K., Meuli R., Reyes D., Stoecker T., Bernstein M.A., Thiran J.P., Krueger G.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
08/2015
Peer-reviewed
Oui
Volume
124
Numéro
Pt A
Pages
157-167
Langue
anglais
Résumé
Imaging in neuroscience, clinical research and pharmaceutical trials often employs the 3D magnetisation-prepared rapid gradient-echo (MPRAGE) sequence to obtain structural T1-weighted images with high spatial resolution of the human brain. Typical research and clinical routine MPRAGE protocols with ~1mm isotropic resolution require data acquisition time in the range of 5-10min and often use only moderate two-fold acceleration factor for parallel imaging. Recent advances in MRI hardware and acquisition methodology promise improved leverage of the MR signal and more benign artefact properties in particular when employing increased acceleration factors in clinical routine and research. In this study, we examined four variants of a four-fold-accelerated MPRAGE protocol (2D-GRAPPA, CAIPIRINHA, CAIPIRINHA elliptical, and segmented MPRAGE) and compared clinical readings, basic image quality metrics (SNR, CNR), and automated brain tissue segmentation for morphological assessments of brain structures. The results were benchmarked against a widely-used two-fold-accelerated 3T ADNI MPRAGE protocol that served as reference in this study. 22 healthy subjects (age=20-44yrs.) were imaged with all MPRAGE variants in a single session. An experienced reader rated all images of clinically useful image quality. CAIPIRINHA MPRAGE scans were perceived on average to be of identical value for reading as the reference ADNI-2 protocol. SNR and CNR measurements exhibited the theoretically expected performance at the four-fold acceleration. The results of this study demonstrate that the four-fold accelerated protocols introduce systematic biases in the segmentation results of some brain structures compared to the reference ADNI-2 protocol. Furthermore, results suggest that the increased noise levels in the accelerated protocols play an important role in introducing these biases, at least under the present study conditions.
Pubmed
Web of science
Création de la notice
25/09/2015 12:54
Dernière modification de la notice
20/08/2019 14:28
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