Article: article from journal or magazin.
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
Journal of Clinical Investigation
PT - Journal Article PT
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 receptor (mIL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). In this study, we investigated the role of IL-6R components in asthma. We observed increased levels of sIL-6R in the airways of patients with allergic asthma as compared to those in controls. In addition, local blockade of the sIL-6R in a murine model of late-phase asthma after OVA sensitization by gp130-fraction constant led to suppression of Th2 cells in the lung. By contrast, blockade of mIL-6R induced local expansion of Foxp3-positive CD4+CD25+ Tregs with increased immunosuppressive capacities. CD4+CD25+ but not CD4+
Adult/Animals/Antibodies/administration & dosage/immunology/Asthma/Pathology/DNA-Binding Proteins/Female/Forkhead Transcription Factors/Homeodomain Proteins/genetics/Humans/Hypersensitivity/Inflammation/Lung/Male/Mice/Mice,Knockout/Ovalbumin/metabolism/Receptors,Cytokine/Receptors,Interleukin-2/Receptors,Interleukin-6/STAT3 Transcription Factor/Signal Transduction/drug effects/Th2 Cells/Trans-Activators
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