The InterPro protein families database: the classification resource after 15 years.

Détails

Ressource 1Télécharger: 25428371_BIB_6EDE56D2C386.pdf (3433.48 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_6EDE56D2C386
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The InterPro protein families database: the classification resource after 15 years.
Périodique
Nucleic Acids Research
Auteur(s)
Mitchell A., Chang H.Y., Daugherty L., Fraser M., Hunter S., Lopez R., McAnulla C., McMenamin C., Nuka G., Pesseat S., Sangrador-Vegas A., Scheremetjew M., Rato C., Yong S.Y., Bateman A., Punta M., Attwood T.K., Sigrist C.J., Redaschi N., Rivoire C., Xenarios I., Kahn D., Guyot D., Bork P., Letunic I., Gough J., Oates M., Haft D., Huang H., Natale D.A., Wu C.H., Orengo C., Sillitoe I., Mi H., Thomas P.D., Finn R.D.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
2015
Volume
43
Numéro
Database issue
Pages
D213-D221
Langue
anglais
Résumé
The InterPro database (http://www.ebi.ac.uk/interpro/) is a freely available resource that can be used to classify sequences into protein families and to predict the presence of important domains and sites. Central to the InterPro database are predictive models, known as signatures, from a range of different protein family databases that have different biological focuses and use different methodological approaches to classify protein families and domains. InterPro integrates these signatures, capitalizing on the respective strengths of the individual databases, to produce a powerful protein classification resource. Here, we report on the status of InterPro as it enters its 15th year of operation, and give an overview of new developments with the database and its associated Web interfaces and software. In particular, the new domain architecture search tool is described and the process of mapping of Gene Ontology terms to InterPro is outlined. We also discuss the challenges faced by the resource given the explosive growth in sequence data in recent years. InterPro (version 48.0) contains 36 766 member database signatures integrated into 26 238 InterPro entries, an increase of over 3993 entries (5081 signatures), since 2012.
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/02/2015 17:42
Dernière modification de la notice
20/08/2019 14:28
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